CHP said officers along with Cal Fire officials responded to the scene of an overturned big rig on the I-10 eastbound at North Indian Canyon Drive in Desert Hot Springs.
The incident happened around 8:00 this morning and caused several lanes heading east to shut down.
Traffic remains closed on the farthest right two lanes heading eastbound on the I-10.
It's unclear if there were any injuries or what caused the big rig to overturn.
Two vehicles involved in crash were towed from the scene, while crews worked to tow the trailer.
No word yet on when lanes will be fully reopened. Commuters heading through the area should expect some traffic delays.
Stay with News Channel 3 for continuing updates.