An accident at 7:40 pm shut down all lanes Eastbound on the I-10 in Banning.
Traffic was slow in the area for several hours, according to the California Highway Patrol.
A vehicle broke down on the side of the road, and may have been the cause of a chain reaction accident.
Four or five vehicles were involved including a work truck that burst into flames.
CHP confirms that several people were taken to the hospital.
All lanes were re-opened later in the evening.
The conditions of the injured are not known.